About the journal
The Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug) published by Islamic Azad University, Shahrekord Branch (Research Center for Medicinal Plants), under licensed Islamic Azad University, Iran.
The Journal of Medicinal Herbs, "J. Med Herb" (Formerly known as Journal of Herbal Drugs or J. Herb Drug) welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. All articles published in "J. Med Herb" will be peer-reviewed.
The "J. Med Herb" invites mainly original articles covering research work results and review articles dealing with issues related to progress in the field of herbal substances and natural products, reports from conferences, meetings, symposium, congress, as well as reviews of books and journals and reviews of various publications on medicinal plants. The articles are published in conformance with international editorial standards. Papers submitted to the J. Med Herb must be written in English. An abstract, being an outline of the main findings, is required in English and Persian (Farsi).
J. Med Herb (An International Journal of Medicinal Herbs) in Google Scholar: H-index=18
Recent Articles
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Open Access Article
1 - The Effects of Cinnamon on Polycystic Ovary Syndrome
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریIssue 3 , Vol. 14 , Summer 2023Background & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me MoreBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. Manuscript profile -
Open Access Article
2 - Crinum glaucum A. chev bulb: Modulation of endogenous antioxidant enzyme in an animal-induced oxidative stress model
اولوفون میلایو اوگونرینولا اولواسی اوگونرینولا اولواتومیلولا اولاتونجی اولوسگون فاجانا موتیو کاظیم ژمیسولا سایبو حبیب بانکول آدمولا آدیوی باباجید الموIssue 3 , Vol. 14 , Summer 2023Background & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopol MoreBackground & Aim: The mechanism of action of Crinum glaucumbulb (Cgb) A. Chev (Amaryllidaceae) is enigmatic. Therefore, this study aimed at investigating the possible modulating properties of an aqueous extract of Cgb on endogenous antioxidant enzymes during lipopolysaccharide (LPS)-induced oxidative stress in a rat model.Experimental: 25 male and 25 female rats were divided into five groups (n=5) each: control group; treatment group, rats were given an aqueous extract of Cgb for 7 days; induced-oxidative stress group, rats were injected with LPS for 4 hours; post-Cgb group, rats were injected with LPS for 4 hours and treated with an aqueous extract of Cgb; and pre-Cgb group, rats were given an aqueous extract of Cgb for 7 days, injected with LPS for 4 hours, and treated with an aqueous extract of Cgb for 7 days. The blood, brain, heart, lungs, liver, and kidneys were harvested for the biochemical analysis. The endogenous antioxidant enzymes (catalase, superoxide dismutase, and glutathione-S-transferase) were analysed spectrophotometrically.Results: The hallmark of LPS is its ability to decrease the activity of oxidative stress marker enzymes, as observed in this study. The pre- and post-administration of an aqueous extract of Cgb significantly (P≤0.05) reversed the damaging effect of LPS by increasing the activities of catalase and superoxide dismutase in the blood and organs of male and female rats, respectively, while plasma glutathione-S-transferase activity was inhibited.Recommended applications/industries: The aqueous extract of Cgb has modulating properties to reduce the action of LPS-induced oxidative stress on endogenous antioxidant enzymes in male and female rats. Manuscript profile -
Open Access Article
3 - Effects of methanol root extract and fractions of Waltheria Indica (linn) on sexual orientation and sexual behavioral parameters in male wistar rats
ساندی سابو ساندی اوتیمنین ساموئل اتوکپاIssue 3 , Vol. 14 , Summer 2023Background & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of m MoreBackground & Aim: Waltheria indica is a shrub whose roots are used in many communities of Northern Nigeria to manage several sexual behavioral disorders; however, there is no scientific study to verify this claim. The aim of the study is to determine the effect of methanol root extract of Waltheria indica and its fractions (ethyl acetate, n-butanol, and residual ethanol) on sexual orientation and sexual behavioral parameters in male albino rats.Experimental: Male rats were divided into five groups each containing 6 rats. Group 1 rats were treated with normal saline. Rats in Groups 2, 3 and 4 were treated with 50, 100 and 200 mg/kg crude extracts while rats in Group 5 were treated with Sildenafil 5 mg/kg. Treatment was administered once daily for 7 days. Female rats were artificially brought to oestrus by administering oestradiol 25 μg/kg and progesterone 500 μg/kg 48 and 8 h respectively prior to mating The mating was done in a 1:1 ratio and mating behaviour was observed on days 1 and 7. Similar procedure was repeated, normal saline, 12.5 and 25 mg/kg of the ethyl acetate, n-butanol and mother liquor fractions, respectively and sexual behavioral parameters were observed.Results: Crude extract and fractions of Waltheria indica significantly increased sexual behavioral parameters, with the n-butanol and mother liquor fractions being most active.Recommended applications/industries: The study showed that methanol root extract of Waltheria indica and its fractions have aphrodisiac activity with the n-butanol and residual methanol fractions being more active. These revelations further substantiates the traditional use of Waltheria indica for the management of infertility in male, thus such discovery can serve as a lead for the development of drugs for the management of sexual dysfunctions. Manuscript profile
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Open Access Article
1 - Study the ethnobotany of medicinal plants in Sirjan, Kerman province, Iran
فریبا شریفی فر عابد کوهپایه محمد مهدی متقی آرزو امیرخسروی الهام پور محسنی نسب منصوره خداشناسIssue 3 , Vol. 1 , Summer 2010Background & Aim: Since traditional knowledge is base of producing new herbals and other natural products, and old people of ancient cities know about characteristics of such herbals, therefore, death of such people will gradually causes demolishing of their knowled MoreBackground & Aim: Since traditional knowledge is base of producing new herbals and other natural products, and old people of ancient cities know about characteristics of such herbals, therefore, death of such people will gradually causes demolishing of their knowledge about herbals. Therefore, it seems it is necessary to register and save such information. The goal of this research is to study and survey about ethnobotany of herbals among people live in Sirjan city in order to learn about way of using these herbals in this area through traditions and customs.Martial & Methods: In this research, at first, the mentioned area divided into different parts by means of geographical maps and then a questionnaire prepared to collect the natives' information about using which parts of herbals in what cases and how to use them. After that, herbals grown in different areas were moved to pharmacy department of Kerman when collected, dried and their herbarium made.Results & Discussion: Finally, 77 species of herbals collected from different areas of Sirjan and registered after identification of each species and their related information (using cases, how and which parts). Due to different cultures of using herbals between natives of Sirjan and other areas of the country and different ways of using various herbals and existence of special herbals in this area, remarkable results about native knowledge of natives using herbals in this area obtained.Conclusion: Considering high potential of herbals in Sirjan, the results of present research and other scientific surveys in this field can provide conditions for better application of herbals in order to prepare products of higher effects and lower harms. Manuscript profile -
Open Access Article
2 - Formulation and characterization of a functional dairy dessert containing Moringa oleifera extract and Inulin
پویا حسن نژاد زهرا بیگ محمدی نفیسه جهانبخشیانIssue 2 , Vol. 14 , Spring 2023Background & Aim: Today, due to the importance of nutrition and the role of food on human health, attention has been paid towards the production of foods rich in functional and beneficial compounds, as well as low calorie products to reduce various diseases such as MoreBackground & Aim: Today, due to the importance of nutrition and the role of food on human health, attention has been paid towards the production of foods rich in functional and beneficial compounds, as well as low calorie products to reduce various diseases such as diabetes, obesity, cardiovascular diseases, etc. The aim of this research was to develop a functional and low-calorie dairy dessert using long-chain inulin and Moringa oleifera extract.Experimental: Moringa oleifera extract (ME) was prepared by the percolation method and used in combination with inulin in the formulation of low-calorie dairy dessert based on maltitol and sucralose as sweeteners. ME was used at 1%, 2% and 3% (w/w) levels and inulin at 5% and 7% levels. The moisture, ash, fat, protein and carbohydrate content, as well as calorie, pH, acidity, soluble solids (brix), syneresis, viscosity, color indices, antioxidant capacity and sensory characteristics (color, flavor, texture, mouth feel and overall acceptability) of the dairy dessert treatments were examined after production.Results: The addition of inulin and ME showed a significant effect on the chemical composition of the desserts and reduced the calories of the treatments compared to the control. Increasing the level of ME did not affect the syneresis and viscosity of the desserts, while by increasing the level of inulin from 5% to 7%, viscosity increased and syneresis decreased significantly (P<0.05). Incorporation of ME into the formulation of dairy dessert also reduced the L* and a* and increased the b* values of the samples (P<0.05). By adding ME and increasing its level from 1% to 3% in the formulation, significant improvement in the antioxidant capacity of the desserts was observed, so that the highest antioxidants capacity was evaluated in the samples containing 7% ME (37.53-37.82%). The results of sensory evaluation indicated that all treatments were acceptable, and the desserts containing lower levels of ME obtained higher flavor, color and overall acceptability scores.Recommended applications/industries: The results of this research demonstrated that inulin as a prebiotic and Moringa oleifera extract as a rich source of bioactive and antioxidant compounds can be used to develop a functional low-calorie dairy dessert. Manuscript profile -
Open Access Article
3 - Preparation of Echium amoenum herbal tea enriched by Malva and Althaea rosea var. nigra
افشین جعفرپور درسا نبی بخشIssue 2 , Vol. 9 , Spring 2019Background & Aim: Echium amoenum is most commonly used herb after tea with high nutritional values. The purpose of this research was to produce Echium amoenum herbal tea, enriched by Malva and Althaea rosea var. nigra, in order to enhance the sensory properties and MoreBackground & Aim: Echium amoenum is most commonly used herb after tea with high nutritional values. The purpose of this research was to produce Echium amoenum herbal tea, enriched by Malva and Althaea rosea var. nigra, in order to enhance the sensory properties and antioxidant activity of herbal tea. Experimental: In this study, antioxidant activity of alcoholic extract was evaluated by DPPH method. The turbidity was determined using spectrophotometer at 800 nm wavelength. Total ash, insoluble ash in acid, moisture content and sensory evaluation were performed according to the national standard methods. The moisture content of the whole samples was higher than the standard range for Echium amoenum. Therefore, for better grinding, the Echium amoenum will be dried again before the packaging process to remove additional moisture absorbed from the environment. Results & Discussion: The results showed that all samples had high antioxidant activity, but the sample containing 0% of the Malva, 30% of Althaea rosea var. nigra and 35% of Echium amoenum showed the most radical inhibition properties (95.04%) (p <0.05). Also, in sensory evaluation, this sample had the highest point with a significant difference (p <0.05) compared to other samples. So, it can be concluded that such a combination of studied herbs is suitable for preparation of herbal tea with high antioxidant and acceptable sensory properties. Industrial/ practical recommendations: The results of this study showed that the use of Echium amoenum and Althaea rosea var. nigra can produce herbal tea as a new product, with high antioxidant and desirable sensory properties. Manuscript profile -
Open Access Article
4 - Botanical, phytochemical and pharmacological properties of quinoa medicinal plant (Chenopodium quinoa Willd.): A review
نسیم پاکباز حشمت امیدی حسنعلی نقدی بادی امیر بوستانیIssue 4 , Vol. 12 , Autumn 2021Background & Aim:Climatic and geographical conditions of Iran and some factors such as climate change, water limitation and the existence of soils with salinity limitation, the cultivation of medicinal plants compatible with such conditions is one of the most import MoreBackground & Aim:Climatic and geographical conditions of Iran and some factors such as climate change, water limitation and the existence of soils with salinity limitation, the cultivation of medicinal plants compatible with such conditions is one of the most important strategies. Quinoa (Chenopodium quinoa Willd) is a valuable medicinal plant and will also contribute to community health. Quinoa has been cultivated in the Andes for about 5,000 years. The largest area under quinoa cultivation in Bolivia is 100,000 ha. In this review, the botany, traditional uses, phytochemical and pharmacological properties of quinoa are discussed.Experimental:In the current review keywords including quinoa and medicinal properties were searched in scientific websites such as Science Direct, PubMed and Google Scholar to compile the botanical and medicinal properties of quinoa (Chenopodium quinoaWilld.).Results:According to the literature review, quinoa protein is 8-22% with proper quality and balance of essential amino acids (lysine, methionine and thyronine). The amount of essential amino acids in quinoa is higher than the daily requirement set by the World Food Organization and the World Health Organization for each person. Compared to other grains, quinoa is high in alpha tocopherols (vitamin E), riboflavin, thiamine and vitamin C, and has 10 times more folic acid. Quinoa seeds are a safe, gluten-free alternative to cereal grains among celiac patients.Recommended applications/ industries:Quinoawith a high amount of biochemical components and pharmacological effects can be used as a valuable herbal drug. It also provides a gluten-free diet, which is beneficial for celiac patients. Its cultivation for industrial and pharmaceutical purposes can help to improve the production of anti-oxidant, anti-diabetic, anti-inflammatory, anti-celiac and anti-cancer drugs in Iran. Manuscript profile -
Open Access Article
5 - Histomorphometric study on the effect of pine tree gum on wound healing of Wistar rats
احمد روزبهانی الهام مقتدایی مصطفی نوربخشIssue 2 , Vol. 9 , Spring 2019Background & Aim: The most therapeutic properties of different species of Pinus class are antimicrobial and anti-inflammatory characteristics, soothing effect, resolver of skin itches, wound, acne and rash healer and improvement of ulcers and chronic lesions. In anc MoreBackground & Aim: The most therapeutic properties of different species of Pinus class are antimicrobial and anti-inflammatory characteristics, soothing effect, resolver of skin itches, wound, acne and rash healer and improvement of ulcers and chronic lesions. In ancient medical literature of Iran, different parts of Pinus classes, particularly its resin, had been used for treating the chronic lesions. This research was conducted to evaluate the effects of resin extract of Pinus eldarica on skin wound healing process in rats. Experimental: In this research, ointment was prepared with 40% of Pinus eldarica resin. Then, 24 Wistar rats divided into 4 groups of 6 rats including resin recipient group (experimental group), positive control group (topical phenytoin), negative control group (Eucerin group) and the control group which received no treatment. After anesthesia, a 2 × 2 cm lesion was created on the lumbar area of the rats. After wounding, ointments plastering was conducted until 21 days after incision. Results & Discussion: On day 3, 7, 21 after incision, morphological and histological characteristics of the wounds were examined. Statistical analysis of results showed that on different days, wound surface was meaningfully decreased (p<0.05) and the effect of phenytoin and pine tree resin on wound healing was equal without significant differences (p<0.05). On the other hand, reducing the wound surface in all three experimented group were greater than the control group. Histopathologically, in resin recipient group, the collagen fiber arrangements were in the best condition and the inflammatory cells were in their lowest numbers maybe because of the effect on fibroblasts. Therefore, preparation and plastering of pine tree resin are recommended for flesh wounds. Industrial/ Practical recommendations: Considering the positive effects of pine resin on wound healing, it can be used in the preparation of burning ointments. Manuscript profile -
Open Access Article
6 - The Effects of Cinnamon on Polycystic Ovary Syndrome
مهرداد استادپور مجید غلامی آهنگران سیدحسین حیدریIssue 3 , Vol. 14 , Summer 2023Background & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal me MoreBackground & Aim: Polycystic ovary syndrome (PCOS) is a major endocrine disorder in young age women affecting their health-related quality of life (HRQOL) and their mental well-being as well. In this review, the authors discuss the effect of cinnamon as an herbal medicine on PCOS in humans and introduce the advantages and efficacy of these herbs on the control of this problem.Experimental: In this review, the authors searched the main related keywords e.g. polycystic, and cinnamon in main biological data centers e.g. Science Direct, Pubmed and Google Scholar. Then, the authors classified articles and only discussed the valid full papers in different categories.Results: The study of papers related to the effect of cinnamon on polycystic ovary syndrome revealed that this herb can control this problem via some route e.g., by control of triglyceride and cholesterol to diminish risk factors of fat deposition and by inhibitory effects on oxidative cascade decreasing the cystic formation process.Recommended applications/industries: The review proposed the positive effect of cinnamon on the control of PCOS in humans. Therefore, supplementary cinnamon on feed can diminish PCOS via some metabolic cycle. Manuscript profile -
Open Access Article
7 - Introductory study of the medicinal plant species of Kazeroon, Fars province
مهدی دولتخواهی مهدی یوسفی جواد باقرنژاد علی دولتخواهیIssue 3 , Vol. 1 , Summer 2010Background & Aim: Kazeroon, with an area of about 4060 km², is situated at 110 km in the west of Shiraz, Fars province, Iran. This area is important for plant biodiversity, due to the presence of some important habitats such as international Lake of Parishan in MoreBackground & Aim: Kazeroon, with an area of about 4060 km², is situated at 110 km in the west of Shiraz, Fars province, Iran. This area is important for plant biodiversity, due to the presence of some important habitats such as international Lake of Parishan in the southeast, woodlands of Quercus persica in the east and branches of Shahpoor river in the west of the region. Therefore, for the old antiquity on this city and high biodiversity on plant species; in this work, the medicinal vascular plants were collected, identified and studied for medicinal usages.Martial & Methods: For this purpose, many specimens were collected during the vegetative seasons in 2007 to 2010. All the specimens were prepared as standard herbarium sheets, identified by using available references and stored in the herbaria of Research Institute of Forests and Rangelands (TARI) and Payam Noor University. Life forms and chorological status of the species were analyzed.Results & Discussion: As a result, 90 species belonging to 87 genera and 39 families of angiosperms were reported from the rangelands around the Kazeroon. Lamiaceae, with 11 species, and Asteraceae with 9 species were the largest families respectively, and Plantago (Plantaginaceae) with 3 species was the largest genus in the medicinal flora of this area.Conclusion: The presence of more than 90 medicinal plant species indicates high biodiversity in the studied region. Furthermore, the findings of this investigation are completely in conformance to the conditions of the area that has a semi-arid climate with dry summers and low rainfall. Manuscript profile -
Open Access Article
8 - Cannabis sativa in ethanol (Monkey Tail) and tramadol induced similar degrees of toxicity in adult female Wistar rats
چینومسو آرون امانوئل اکوبوگو سلیمان ایجیوما رابرت اوروکو اوچه آرونسی کینگزلی اوگووانی ویکتور اوگویکIssue 1 , Vol. 13 , Winter 2022Background & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxi MoreBackground & Aim: This study was designed to evaluate the toxic effects of Cannabis sativa local gin formulation (CSLGF) and tramadol in adult female Wistar rats.Experimental: Cannabis sativa local gin formulation (CSLGF) was prepared and was subjected to acute toxicity tests together with tramadol. In the main study, 25 rats were assigned into 5 groups (n = 5) in which the group 1 received no treatment, groups 2 and 3 received 25 and 50 mg/kg of tramadol, respectively while groups 4 and 5 received 25 and 50 mg/kg of CSLGF, respectively, for 21 days before the rats were sacrificed.Results: Acute toxicity results indicated narrow margins of safety for CSLGF and tramadol with LD50 values of 123.0 and 133.0 mg/kg body weight, respectively. The rats treated with CSLGF lost weight significantly while that administered tramadol had lower weight gains when compared with the control (P<0.05). The red blood cell counts, packed cell volume and haemoglobin concentrations were significantly lowered by CSLGF (P<0.05). However, a significant increase in the number of platelets and white blood cells were observed in groups treated with both CSLGF and tramadol. Results of biochemical changes showed a significant increase in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total bilirubin, urea and creatinine with a concurrent decrease in total protein, albumin and globulin values following treatment with both agents (P<0.05), but serum electrolytes concentrations were not significantly altered (P>0.05). Treatment with CSLGF and tramadol also significantly lowered glutathione, superoxide dismutase and catalase activities but increased malondialdehyde concentrations when compared with control.Recommended applications/industries: The findings show that although the toxic effects of CSLGF and tramadol in rats are similar, CSLGF appears to have higher toxicity potentials. Extending the current control on tramadol to CSLGF (monkey tail) is urgently needed in Nigeria to protect human lives. Manuscript profile -
Open Access Article
9 - Chemical composition and biological activities of Nepeta hindostana (Roth) Haines, Nepeta graciliflora Benth. and Nepeta cataria L. from India
مونیکا جوشی راوندرا کومار ام پراکاش آنیل پانت D. راواتIssue 2 , Vol. 12 , Spring 2021Background & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present st MoreBackground & Aim:Intraditional medicine system, Nepeta species are widely used to reduce chicken pox, tuberculosis, malaria, pneumonia, influenza, measles, stomach disorders, eye complaints, respiratory disorders, asthma, colds, coughs etc. The aim of the present study was to evaluate the chemical composition and biological activities of the essential oils from three species of genus Nepeta viz: Nepeta hindostana (Roth) Haines (NHO), Nepeta graciliflora Benth (NGO) and Nepeta cataria L (NCO).Experimental: The essential oils were analysed by the combination of GC and GC-MS. Antioxidant activity was tested by using reducing power assay, metal chelating of Fe2 +assay, and DPPH radical scavenging assay. In-vitro antinflammatory activity was evaluated using albumin denaturation assay and anti-diabetic activity was determined by using α-amylase assay.Results: The major components present in NCO, NHO and NGO were cis-nepetalactone (69.78%), β-farnesene (43.41%) and sesquisabinene (28.75%), respectively. NCO showed the highest percentage inhibition of DPPH radical (IC50=5.89 µl/ml) followed by NHO (IC50=8.63 µl/ml) and then NGO (IC50=13.81 µl/ml). In terms of reducing power assay and metal chelating of Fe2+ assay, the highest antioxidant activity was also shown by NCO. Among the tested essential oil, NCO showed highest in-vitro anti-inflammatory potential (IC50 18.463±0.14 µg/ml) followed by NGO and NHO with IC50 22.035±0.11 µg/ml and 26.17±0.14 µg/ml, respectively. NHO showed maximum antidiabetic activity with IC50 8.92±0.10 µg/ml of α-amylase.Recommended applications/industries: On the basis of present research work it is marked that the essential oil of Nepeta hindostana (Roth) Haines, Nepeta graciliflora Benth. and Nepeta cataria L. is a potent antioxidant, anti-inflammatory and anti-diabetic agent indicating their potentiality in the field of food, pharmaceutical and cosmetic industry Manuscript profile -
Open Access Article
10 - Phytochemical analysis, phenolic content and antioxidant activity of methanolic extract of Caryopteris odorata D.Don.Robin
آرکانا جوشی آنیل پانت اَوم پراکاش مارکین استوکی والاری ایزیدورIssue 4 , Vol. 9 , Autumn 2019Background & Aim:Caryopteris odorata is an aromatic shrub of family verbenaceae growing in tropical to subtropical regions. Various traditional applications of this plant have been documented guiding us to investigate the pharmacological activities and to further in MoreBackground & Aim:Caryopteris odorata is an aromatic shrub of family verbenaceae growing in tropical to subtropical regions. Various traditional applications of this plant have been documented guiding us to investigate the pharmacological activities and to further investigate the chemical composition. Experimental: Methanolic extract of aerial parts of Caryopteris odorata was investigated for antioxidant activity and the major phyto-constituents and total phenolic content were screened. The antioxidant activity was determined by measuring the scavenging activity using DPPH radical scavenging, NO radical scavenging, so radical scavenging activity, Metal chelating and reducing power assay. The antimicrobial efficacy was determined using agar well diffusion method against gram positive as well as gram negative bacteria. Sensitivity in terms of zones of inhibition and phytochemical composition of the extracts were also determined. In vitro anti-inflammatory activity was evaluated using albumin denaturation method. Diclofenec Sodium was used as a standard drug for the study of anti-inflammatory activity. Results: The results revealed that, methanolic extracts possess broad spectrum antibacterial activity against three microorganisms. Phytochemical analysis revealed the presence of diterpenes carbohydrates, glycosides, sterols and triterpenoids, aliphatic acids , tocopherols and phenolics. The methenolic extract exhibit strong antioxidant activity (IC50 values for DPPH assay 164.60 ±0.37 mg/ml, for metal chelating 280.30 ± 3.28 mg/ml, for reducing assay 80.38 ± 0.79 mg/ml, respectively). The extract also showed in vitro anti-inflammatory activity by inhibiting the heat induced albumin denaturation with IC50 value as 497.22 ± 1.34 mg/ml, respectively. From the result, it is concluded that the C.odorata possess a rich amount of different class of compounds and further the phytochemicals present in the C.odorata extract may be responsible for the antimicrobial, antioxidant and anti-inflammatory activity. Recommended applications/industries: The results obtained from various activities suggest Caryopteris odorata application as natural alternative antioxidant, anti-inflammatory and antimicrobial reagent. Manuscript profile
