Nephroprotective activity of Mammea africana stem bark against paracetamol induced kidney injury

Document Type: Original article

Authors

Department of Pharmacology and Toxicology Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Abstract

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (K+, Na+, Cl- and HCO-3),  antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and histopathological study of the liver. Results & Discussion: The administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. The electrolytes levels were not affected. Histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of M. africana Recommended applications/industries: The results show that the stembark extract of Mammea africana has nephroprotective potential which may be due to its antioxidant effect activity.

Keywords


Article Title [Persian]

اثرات نفروپروتکتیو عصاره برگ Mammea africana علیه آسیب کلیه ناشی از پاراستامول

Authors [Persian]

  • چودفیوم اوکوکون
  • بائو میشل
Abstract [Persian]

Background & Aim: Mammea africana sabine (Guttiferae) stembark commonly used traditionally to treat various diseases and ailments was evaluated for nephroprotective activity against paracetamol – induced kidney injury in rats to confirm its use in the treatment of kidney diseases. Experimental:  The nephroprotective effect of the extract was evaluated by the determination of some kidney function parameters such as serum urea and creatinine, electrolyes (K+, Na+, Cl- and HCO-3),  antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), malondialdehyde (MDA) and histopathological study of the liver. Results & Discussion: The administration of the stembark extract caused significant dose-dependent reduction of high levels of serum creatinine and urea. The electrolytes levels were not affected. Histology of the kidney sections of extract and silymarin- treated animals showed reductions in the pathological features compared to the paracetamol- treated animals. The chemical pathological changes were consistent with histopathological observations suggesting marked nephroprotective effect of the stembark extract of M. africana Recommended applications/industries: The results show that the stembark extract of Mammea africana has nephroprotective potential which may be due to its antioxidant effect activity.

Keywords [Persian]

  •  Mammea africana  Nephroprotective  Antioxidant  Kidney
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