Antimalarial activities of Breynia Nivosa

Document Type: Original article

Authors

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,Uyo, Nigeria;

2 Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria;

3 Department of Biological Sciences, University of Abuja, Nigeria;

Abstract

Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p  Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.

Keywords


Article Title [Persian]

فعالیت های ضدمالاریا Breynia Nivosa

Authors [Persian]

  • جود اکوکون 1
  • کوفرش داویس 2
  • آزار ب.آ 3
1 گروه فارماکولوژی و سم شناسی، دانشکده داروسازی، دانشگاه Uyo، Uyo، نیجریه.
2 گروه فیزیولوژی، دانشکده علوم پزشکی، دانشگاه Uyo، Uyo، نیجریه.
3 گروه علوم زیستی، دانشگاه ابوجا، نیجریه.
Abstract [Persian]

Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p     Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.

Keywords [Persian]

  • Breynia nivosa Antiplasmodial ضدمالاریا درمان گیاهی
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