Okokon, J., Davis, K., B. A, A. (2015). Antimalarial activities of Breynia Nivosa. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 5(4), 169-173.
Jude E. Okokon; koofreh Davis; Azare B. A. "Antimalarial activities of Breynia Nivosa". Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 5, 4, 2015, 169-173.
Okokon, J., Davis, K., B. A, A. (2015). 'Antimalarial activities of Breynia Nivosa', Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 5(4), pp. 169-173.
Okokon, J., Davis, K., B. A, A. Antimalarial activities of Breynia Nivosa. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 2015; 5(4): 169-173.
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo,Uyo, Nigeria;
2Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria;
3Department of Biological Sciences, University of Abuja, Nigeria;
Abstract
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.
1گروه فارماکولوژی و سم شناسی، دانشکده داروسازی، دانشگاه Uyo، Uyo، نیجریه.
2گروه فیزیولوژی، دانشکده علوم پزشکی، دانشگاه Uyo، Uyo، نیجریه.
3گروه علوم زیستی، دانشگاه ابوجا، نیجریه.
Abstract [Persian]
Background & Aim: Antiplasmodial activity of leaf extract of Breynia nivosa was evaluated to ascertain the folkloric claim of its antimalarial activity. Experimental: The crude leaf extract (75 – 225 mg/kg), of Breynia nivosa was investigated for antiplasmodial activity against chloroquine sensitive Plasmodium berghei infections in mice. The antiplasmodial activity during early and established infections as well as prophylactic were investigated. Artesunate 5 mg/kg and pyrimethamine 1.2 mg/kg were used as positive controls. Thin films made from tail blood of each mouse were used to assess the level of parasitaemia of the mice. Results & Discussion: The extract dose-dependently reduced parasitaemia induced by chloroquine sensitive Plasmodium berghei infection in prophylactic, suppressive and curative models in mice. These reductions were statistically significant (p<0.001). They also improved the mean survival time (MST) from 11 to 27 days relative to control control (p Industrial and practical recommendations: The plant, Breynia nivosa, possesses antimalarial property which can be exploited in the treatment of malaria.
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