Antidiabetic and hypolipidaemic activities of Solenostemon monostachyus

Document Type: Original article

Authors

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo – Nigeria

2 Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu Campus, Imo State

3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State

Abstract

Background & Aim: Solenostemon monostachyus has remain invincible in Ibibio ethnomedicine for the management of numerous ailment including diabetes mellitus. Many of these ethnomedicinal claims are yet to be pharmacologically verified. The purpose of this study therefore was to subject the extract/fractions of Solenostemon monostachyus used in folkloric management of diabetes to scientific assay. Experimental: The crude extract and fractions of S. monostachyus (75 -225 mg/kg) were evaluated for antidiabetic activity in alloxan – induced diabetic rats. The antidiabetic activity during acute and prolong studies were investigated. Glibenclamide, 10 mg/kg, was used as positive control. The Blood Glucose Level (BGL) was measured by using a glucometer and the various lipids level were estimated using Randox diagnostic kits. Results & Discussion: Treatment of alloxan diabetic rats with the extract/fractions caused a significant (P<0.001) reductions in BGL of the diabetic rats both in acute and prolong treatment (2 weeks). The activities of extract and fractions were comparable to that of glibenclamide in prolonged study. S. monostachyus treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and an increase in HDL cholesterol in the treated diabetic group. Industrial and practical recommendations: These results suggest that the extract of S. monostachyus possesses antidiabetic and hypolipidaemic effect on alloxan-induced diabetic rats which can be exploited in the management of diabetes.

Keywords


Article Title [Persian]

بررسی فعالیت ضد دیابتی و کاهش دهندگی چربی در Solenostemon monostachyus

Authors [Persian]

  • جواد اکوکون 1
  • لوییس آمازو 2
  • لوکی نوییدا 3
1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo – Nigeria
2 2Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu Campus, Imo State
3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State
Abstract [Persian]

مقدمه و هدف: Solenostemon monostachyus  هنوز اهمیت خود را به عنوان یک گیاه دارویی سنتی در درمان برخی از بیماریها از جمله دیابت ملیتوس در بین مردمان ایبی بیو از دست نداده است. البته بسیاری از این ادعاهای دارویی هنوز نیاز به تایید از نظر علوم دارویی دارند. بنابراین هدف در این تحقیق استفاده از عصاره Solenostemon monostachyus  برای کنترل دیابت در یک ارزیابی علمی بوده است. روش تحقیق: عصاره خام و فراکشنهایS. monostachyus (225-75 میلی گرم در کیلوگرم) برای ارزیابی فعالیت ضد دیابتی در موشهای دیابتی شده با آلوکسان مورد بررسی قرار گرفته و فعالیت ضد دیابتی در مطالعات حاد و بلند مدت ارزیابی شد. از گلی بن کلامید به میزان 10 میلی گرم در کیلوگرم به عنوان نمونه کنترل مثبت استفاده شد. سطح گلوکز خون(BGL) با استفاده از گلوکومتر اندازه گیری شده و سطح لیپیدهای مختلف با استفاده از کیتهای شناسایی Randox تخمین زده شد. نتایج و بحث: تیمار موشهای دیابتی شده با آلوکسان توسط عصاره/فراکشنهای عصاره باعث کاهش معنی داری (P<0.001) در BGL در مطالعات حاد و بلند مدت شد( دو هفته). فعالیت عصاره و فراکشنها قابل مقایسه با گروه گلی بن کلامید در بلند مدت بود. تیمار با S. monostachyus  باعث کاهش قابل توجه در کلسترول کل، تری گلیسریدها، LDL، VLDL و افزایش در HDL در گروه دیابتی تیمار شده شد. توصیه های کاربردی/ صنعتی: نتایج نشان داد که عصاره S. monostachyus  دارای تاثیرات ضد دیابتی و کاهنده چربی بر روی موشهای دیابتی شده باآلوکسان است که می تواند به منظور کنترل دیابت مورد بهره برداری قرار گیرد.

Keywords [Persian]

  • Solenostemon monostachyus
  • ضد دیابتی
  • کاهنده چربی
  • دیابت
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