Analgesic and anti-inflammatory activities of Zea mays leaves

Document Type: Original article

Authors

1 Department of pharmacology and toxicology, Faculty of pharmacy, University of Uyo, Uyo, Nigeria

2 Department of physiology, Faculty of basic medical sciences, University of Uyo, Uyo, Nigeria

3 Department of chemistry, University of Uyo, Uyo, Nigeria

Abstract

Background & Aim:Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. Experimental: The effects of ethanol leaf extract of Zea mays (170 -510 mg/kg) on experimentally induced inflammation and pain were studied in rats using Carrageenin, egg albumin  and xylene-induced inflammation as well as acetic acid-induced writhing and thermal induced pain models. The GCMS analysis of the most active fraction was carried out.
Results: The extract (170 -520 mg/kg) inhibited inflammation and pains caused by different phlogistic agents used in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001), though incomparable to that of the standard drugs used (ASA and indomethacin). The GC-MS revealed the present of polyunsaturated fatty acids and phenolic compounds which may be responsible for the observed activities of the extract. Recommended applications/industries: The present study demonstrates that leaf extract of Zea mays might to be useful for the treatment of inflammation and pains.

Keywords


Article Title [Persian]

بررسی فعالیت ضد درد و ضد التهاب در برگهای Zea mays

Authors [Persian]

  • جود اکوکون 1
  • کوفره دیویز 2
  • باسی آنتیا 3
1 Department of pharmacology and toxicology, Faculty of pharmacy, University of Uyo, Uyo, Nigeria
2 Department of physiology, Faculty of basic medical sciences, University of Uyo, Uyo, Nigeria
3 Department of chemistry, University of Uyo, Uyo, Nigeria
Abstract [Persian]

Background & Aim:Zea mays leaf used traditionally in Ibibio ethno medicine in Southern Nigeria to treat malaria and other inflammatory diseases. These anti-inflammatory and analgesic properties were evaluated against experimentally induced inflammation and pains using standard models. Experimental: The effects of ethanol leaf extract of Zea mays (170 -510 mg/kg) on experimentally induced inflammation and pain were studied in rats using Carrageenin, egg albumin  and xylene-induced inflammation as well as acetic acid-induced writhing and thermal induced pain models. The GCMS analysis of the most active fraction was carried out. Results: The extract (170 -520 mg/kg) inhibited inflammation and pains caused by different phlogistic agents used in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.05, 0.01, 0.001), though incomparable to that of the standard drugs used (ASA and indomethacin). The GC-MS revealed the present of polyunsaturated fatty acids and phenolic compounds which may be responsible for the observed activities of the extract. Recommended applications/industries: The present study demonstrates that leaf extract of Zea mays might to be useful for the treatment of inflammation and pains.

Keywords [Persian]

  • Zea mays
  • ضد التهاب
  • ضد درد
  • GC-MS
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