The examination of the changes in serum biochemical factors caused by the ingestion of oral Sumac in dogs

Document Type: Original article

Authors

Department of Clinical Science, faculty of veterinary medicine, Islamic azad university of Shahrekord, Shahrekord, Iran

Abstract

Introduction and goal: Today, the researchers have found that many recent diseases are due to cellular oxidative stress which is caused by the imbalance of the formation and neutralization of free radicals. Including weak immune system, cancers, inflectional diseases, aging body and Diabetes. Diabetes is the most common endocrine disease in the world that is referred to as the mother of the diseases for affecting the whole body such as digestive system, kidneys, eyes and most importantly cardiovascular system (atherosclerosis) which is the main cause of death in the developed world.
Materials and Method: In this research 6 local dogs were used for 10 days and divided into 3 groups of 2:the control group, the group receiving 10 mg/kg of Sumac and the group receiving 5 mg/kg of Sumac. At the end of the oral Sumac ingestion, blood samples were taken and the relevant tests were done.
Results and Discussion: The results of the present research indicated that adding Sumac powder in dog feed for 10 days, significantly decreased serum glucose, triglyceride and liver enzymes Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) parameters  (p< 0.05). However, there was no significant differences between the cholesterol level of the examined groups during the research specified period of time (p> 0.05).
Industrial / Practical recommendation: Considering that the results of the present study are consistent with similar research, anti-diabetic, anti-atherosclerotic and antioxidant effects of Sumac can be concluded. It can also be used as a replacement for chemical drugs.

Keywords


Article Title [Persian]

بررسی تغییرات فاکتورهای بیوشیمیایی سرم ناشی از مصرف گیاه سماق (Rhus coriaria L) در سگ

Authors [Persian]

  • حسن میرمحمدی
  • سام ترکان
  • محسن جعفریان دهکردی
دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
Abstract [Persian]

مقدمه   و هدف: امروزه محققان   دریافته اند بسیاری از بیماری های امروزه ناشی از استرس اکسیداتیو سلولی که   نتیجه عدم تعادل بین تشکیل و خنثی سازی رادیکال های آزاد بوده و شامل   ضعف سیستم   ایمنی، سرطان ها ، بیماری های عفونی،پیری بدن و همچنین افزایش بروز یکی از شایع ترین بیماری های غدد و متابولیکی در جهان یعنی   بیماری دیابت می شود که از آن با نام ام‌الامراض یاد   می شود چرا که تمام بدن از جمله سیستم گوارش، کلیه، چشم و از همه مهم تر سیستم   قلب و عروقرا   تحت تاثیر خود قرار می‌دهد که شایع ترین علت وقوع مرگ و میر در جهان پیشرفته (آرترواسکروزیس) است.
روش تحقیق: در این تحقیق از 12 قلاده سگ نژاد بومی به مدت   ده روز استفاده شد، سپس به سه گروه چهار تایی تقسیم شدند که شامل گروه کنترل،   گروه دریافت کننده سماق به میزان10 گرم و گروه دریافت کننده سماق به میزان 5 گرم به   ازای هر کیلوگرم خوراک مصرفی هر قلاده سگ بوده و پس از اتمام دوره تجویز خوارکی پودر سماق اقدام به خونگیری و سپس   آزمایشات مربوطه انجام شد.
نتایج و بحث:  نتایج این تحقیق نشان داد که مصرف پودر خوراکی سماق همراه   با غذا در سگ ها به مدت 10 روز باعث کاهش معنی دار در فراسنجه های کلوگز سرم   خون، تری گلیسرید و همچنین آنزیم های کبدی آلانین   آمینوترانسفراز (ALT   ) و آسپارتات آمینوترانسفراز(AST) (05/0p < ) شد .این در حالی است که سطح کلسترول سرم تحت تاثیر مصرف سماق قرار نگرفت   (05/0p   > ). 
توصیه کاربردی/صنعتی: با توجه به اینکه نتایج این تحقیق با تحقیقات مشابه هم خوانی دارد می توان به اثرات آنتی دیابتی، آنتی آترواسکروز، آنتی اکسیدانی گیاه سماق پی برد و همچنین از آن به عنوان جایگزین داروهای شیمیایی استفاده کرد.

Keywords [Persian]

  • بیوشیمی
  • سرم
  • سماق
  • سگ
Abbass, M., Mahmoud, A., Hussein, M. and Gabr, S.A. 2012. Assessment of antioxidant changes of aged rats treated with Sumac extract. Journal of American Science, 8: 553-558.

Ahmadian Atari, M., Amin, G.H., Fazeli, M.R. and Jamalifar, H. 2007. Survey of the antibacterial activity of sumac fruit. Medical Plants Periodical, 1: 1-9.

Amin, G.R. 1991. Popular medicinal plants of Iran. Iranian Research Institute of Medicinal Plants Tehran, 3:1-8.

Charlton, M., Sreekumar, R., Rasmussen, D., Lindor, K., and Nair, K.S. 2002. Apolipoprotein synthesis in nonalcoholic steatohepatitis. Hepatology, 35(4), 898-904.

Giancarlo R.S., Rosa, L.M., Nadjafi, F. and Francesco, M. 2006. Hypoglycaemic activity of two spices extracts: Rhus coriaria L. and Bunium persicum Boiss. Natural Product Research, 20(9): 882-886.

Hemmatabadi, M. and Larijani, B. 2009. A review of the role of oxidative stress and antioxidant therapy in diabetes. Iranian Journal of Diabetes and Metabolism, 9: 1-6.

Mozafarrian, V. 1998. Dictionary of the names of Iranian plants. Farhange Moaser, Tehran, p. 29-31.

Mavlyanov, S., Islambekov, S.Y., Karimdzhanov, A. and Ismaikov, A. 1997. Anthocyans and organic acids of the fruits of some species of sumac. Chemistry of Natural Compounds, 33(2): 209-209.

Naderi, GH., Asgary, S., Gharipour, M., Taher, M. and Khosravi, E. 2008. Antioxidant effect of Piper nigrum on hepatocyte membrane and LDL oxidation and non. cell, 1050-106.

Nuraliev, I. and Avezov, G. 1991. The efficacy of quercetin in alloxan diabetes. Eksperimental'naia I klinicheskaia Farmakologiia, 55(1): 42-44.

Okopien, B., Krysiak, R., Madej, A., Belowski, D., Zieliñski, M., Kowalski, J. and Herman, Z. S. 2004. Effect of simvastatin and fluvastatin on plasma fibrinogen levels in patients with primary hypercholesterolemia. Pharmacological Reports, 56(6), 781-788.

Özcan, M.  and Haciseferogullari, H. 2004. A condiment sumac (Rhus coriaria L.) fruits: some physicochemical properties. Bulgarian Journal of Plant Physiology, 30(3-4): 74-84.

Özcan, M. 2003. Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil. Journal of Medicinal Food, 6(3): 267-270.

Pourahmad, J., Eskandari, M. R., Shakibaei, R. and Kamalinejad, M. 2010. A search for hepatoprotective activity of aqueous extract of Rhus coriaria L. against oxidative stress cytotoxicity. Food and Chemical Toxicology, 48(3): 854-858.

Perchellet, J. P., Gali, H. U., Perchellet, E. M., Klish, D. S. and Armbrust, A. D. 1992. Antitumor-promoting activities of tannic acid, ellagic acid, and several gallic acid derivatives in mouse skin Plant Polyphenol. Springer, pp. 783-801.

Raufi, A., Mardani, M., Sabagh, M., Delfan, B. and Tarrahi, M. 2009. Study on the effect of Rhus Coriaria (Sumac) on LDL Cholesterol level compared with levostatin. Journal of Ilam University of Medical Science, 17: 51-55.

Sheikhhasan, M., Ghiasi, M., Tabatabie Ghomi, R. and Kolhar, N. 2014.  Isolation of mesenchymal stem cells from adipose tissue for use in tissue engineering dog. First National Congress of Biology and Natural Sciences Iran, pp 145.

Salimi, Z., Eskandary, A., Headari, R., Nejati, V., Moradi, M. and Kalhori, Z. 2015. Antioxidant effect of aqueous extract of sumac (Rhus coriaria L.) in the alloxan-induced diabetic rats. Indian Journal of Physiol Pharmacol, 59(1): 87-93.

Setorki, M., Rafieian, M., Heidarian, E., Ghatreh, K., Shahinfard, N., Ansari, R. and Forouzandeh Z. 2012. Effect of Rhus coriaria consumption with high cholesterol food on some atherosclerosis risk factors in rabbit. Journal of Babol University of Medical Sciences, 14: (3) 38-45.

Shafiei, M., Nobakht, M. and Moazzam, A. 2011. Lipid-lowering effect of Rhus coriaria L.(sumac) fruit extract in hypercholesterolemic rats. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 66(12), 988-992.

Shahbazi, P. and Maleknia N. 2005. General Biochemistry. Tehran University Press, Tehran. p 502.

Tohouri, S.H. 2010. Encyclopedia of medical plants. Qom.Padideh Danesh Puplication: P. 267-269.

 Talei, G. R., Meshkat, A. M. and Delfan, B. 2004. Antibacterial activity of fruit, leaves extracts of artemisia persica boiss, rhus coriaria, ephedra intermedia and daphne mucronata royle of lorestan, 12: 78-84.

Zargham, H. and Zargham, R. 2008. Tannin extracted from Sumac inhibits vascular smooth muscle cell migration. McGill Journal of Medicine, 11(2): 119.

 Zargari, A. 1997. Iranian medicinal plants. Tehran University Publications, Tehran, 1: 558-565.