Mahboubi, M., Memar Kermani, M., Karbasi Zadeh, H. (2017). Main ingredients in herbal formulation may act as preservative agent. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8(2), 116-120. doi: 10.18869/JHD.2017.116
Mohaddese Mahboubi; Maryam Memar Kermani; Hasan Karbasi Zadeh. "Main ingredients in herbal formulation may act as preservative agent". Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8, 2, 2017, 116-120. doi: 10.18869/JHD.2017.116
Mahboubi, M., Memar Kermani, M., Karbasi Zadeh, H. (2017). 'Main ingredients in herbal formulation may act as preservative agent', Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8(2), pp. 116-120. doi: 10.18869/JHD.2017.116
Mahboubi, M., Memar Kermani, M., Karbasi Zadeh, H. Main ingredients in herbal formulation may act as preservative agent. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 2017; 8(2): 116-120. doi: 10.18869/JHD.2017.116
Main ingredients in herbal formulation may act as preservative agent
1Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran
2Formulation Department, Medicinal Plant Research Center of Barij, Kashan, Iran
Abstract
Background & Aim:Nowadays, the use of chemical preservatives has been limited due to the controversial adverse effects. In this study, we evaluated the preservative potency of product with active herbal ingredients (Barij Baby cream) in contrast with the same products with two different chemical preservatives including methylparaben plus propylparaben and potassium sorbate plus sodium benzoate. Experimental: The efficacy of herbal formulation against pathogens (E. coli, P. aeruginosa, C. albicans, A. niger, S. aureus) was evaluated by antimicrobial effectiveness test during 28 days. Results: 2 log reductions in bacterial counts at 14 days from the initial count, and no growth in bacterial and fungal (molds and yeasts) counts at 28 days from the 14 days is essential for accepting the antimicrobial effectiveness of category 2 products in United States Pharmcopia (USP). Our results of antimicrobial effectiveness test showed that the active herbal ingredients in Barij Baby cream passed the USP criteria as chemical preservatives in the same product. Recommended applications/industries: Therefore, in designing new herbal products, it is essential to evaluate the antimicrobial effectiveness of products before supplemented the product with chemical preservatives.
عملکرد اجزای اصلی در یک فرمول گیاهی به عنوان ماده محافظ ضدمیکروبی
Authors [Persian]
محدثه محبوبی1; مریم معمار کرمانی1; حسن کرباسی زاده2
1گروه میکروبیولوژی، مرکز تحقیقات گیاهان داروئی، کاشان، ایران
2گروه فرمولاسیون، مرکز تحقیقات گیاهان دارویی باریج، کاشان، ایران
Abstract [Persian]
مقدمه و هدف: امروزه استفاده از مواد محافظ ضدمیکروبی شیمیایی به خاطر اثرات جانبی چالش برانگیز آن محدود شده است. در این مطالعه ما اثرات ماده محافظ ضدمیکروبی فرآورده با اجزای گیاهی (کرم کودک باریج) را در مقایسه با همان فرمولاسیون با متیل و پروپیل پارابن و یا با پتاسیم سوربات و سدیم بنزوات بررسی کردیم. روش تحقیق: مقایسه اثربخشی سه فرمولاسیون گیاهی حاوی مواد محافظ ضدمیکروبی مختلف در مقابل پاتوژنهای ایکولای، سودوموناس آئروجینوزا، کاندیدا آلبیکانس، آسپرژیلوس نایجر و استافیلوکوکوس اورئوس با استفاده از تست اثربخشی ماده محافظ ضدمیکروبی در طی 28 روز انجام گرفت. نتایج و بحث: کاهش دو لگاریتم در شمارش باکتریایی در روز چهاردهم از شمارش اولیه و عدم رشد تعداد باکتری و قارچ (کپک و مخمر) در روز بیست و هشتم نسبت به روز چهاردهم معیار قابل قبول برای پدیرش اثربخشی ماده محافظ ضدمیکروبی فرآورده های گروه دوم فارماکوپه آمریکا (USP) است. نتایج اثربخشی ماده محافظ ضدمیکروبی نشان داد که اجزای فعال گیاهی کرم کودک باریج معیارهای قابل قبولUSP را به مانند ماده محافظ ضدمیکروبی شیمیایی دارا می باشد. توصیهکاربردی/صنعتی: در طراحی یک فرمول گیاهی جدید ضروری است که اثربخشی فرآورده قبل از اضافه شدن مواد محافظ ضدمیکروبی شیمیایی ارزیابی شود.
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