Saghaei, F., Motamedi, S. (2017). The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8(3), 179-184. doi: 10.14196/JHD.2018.179
Firoozeh Saghaei; Sadegh Motamedi. "The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse". Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8, 3, 2017, 179-184. doi: 10.14196/JHD.2018.179
Saghaei, F., Motamedi, S. (2017). 'The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse', Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 8(3), pp. 179-184. doi: 10.14196/JHD.2018.179
Saghaei, F., Motamedi, S. The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse. Journal of Herbal Drugs
(An International Journal on Medicinal Herbs), 2017; 8(3): 179-184. doi: 10.14196/JHD.2018.179
The antinociceptive and anti-inflammatory effects of hydro alcoholic extract of Satureja bachtiarica on mouse
Department of Pharmacology, Faculty of Veterinary Medicine, Islamic Azad University, Shahrekord branch, Shahrekord, Iran
Abstract
Background & Aim: The use of anti-nociceptive and anti-inflammatory drugs in clinical medicine is necessary and unavoidable. Since the use of synthetic drugs is associated with numerous side effects, the application of complementary therapies such as herbal medicine can accompany with less side effects while having anti-inflammatory and analgesic properties. Satureja bachtiarica contains different active compounds such as Thymol, Para syman, Menton and Carvacrol which may be involved in the control of nociception and/or inflammation. Experimental: 75 male mice (weighing 30 -20 g) were divided to 15 groups. Analgesic and anti-inflammatory effects of hydroalcoholic Satureja bachtiarica extract at doses of 400, 600, 800 mg/kg were evaluated by writhing, formalin and xylene tests. Morphine (10 mg /kg) and dexamethasone (10 mg/kg) were considered as positive controls in analgesic and anti-inflammatory tests, respectively. Results & Discussion: Different doses of hydroalcoholic extract of Satureja bachtiarica significantly reduced pain in comparison to control groups, however, the anti-inflammatory effect of this drug evaluated by xylene test, has not been established which needs further examination through other tests. Industrial / Practical recommendation: According to present results, the analgesic effect of Satureja bachtiarica was comparable to morphine. However, it seems that further research is needed in the future to take advantage of this plant in relieving pain.
اثر ضد درد و ضد التهاب عصاره هیدروالکلی گیاه مرزه بختیاری بر موش سوری
Authors [Persian]
فیروزه سقایی; صادق معتمدی
گروه علوم پایه، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
Abstract [Persian]
مقدمه و هدف: استفاده از داروهای ضد درد و ضد التهاب در طب بالینی ضروری و اجتناب ناپذیر است. از طرفی مصرف روز افزون داروهای شیمیایی، عوارض جانبی متعددی را به همراه دارد که اغلب خطرناک بوده و لذا استفاده از گیاهان دارویی با عوارض جانبی احتمالی کمتر، به عنوان تسکین درد و التهاب از اهمیت بالایی برخوردار است. گیاه مرزه بختیاری با داشتن ترکیبات تیمول، پاراسایمن، منتون و کارواکرول احتمالاً می‌تواند درد را تسکین و التهاب را کاهش دهد. روش تحقیق: از 75 سر موش سوری نر (با وزن 30 - 20 گرم) در 15 گروه آزمایشی استفاده شد. روش کار شامل آزمون رایزینگ و فرمالین برای بررسی اثرات ضد درد و آزمون گزیلن برای بررسی اثر ضد التهاب بود. عصاره گیاه در دوزهای 400 و 600 و 800 میلی‌گرم بر کیلوگرم وزن موش، مرفین ( 10میلی گرم بر کیلوگرم) در آزمون درد و دگزامتازون (10 میلی گرم بر کیلوگرم) در آزمون التهاب به عنوان کنترل مثبت استفاده شدند. نتایج و بحث: عصاره الکلی گیاه مرزه بختیاری در مقایسه با گروه کنترل به طور معناداری سبب کاهش درد گردید ولی اثر ضد التهاب این دارو با آزمون گزیلن اثبات نشد که نیاز به بررسی بیشتر از طریق آزمونهای دیگر دارد. توصیه کاربردی/صنعتی: با توجه به نتایج، اثر ضد درد عصاره با مرفین قابل مقایسه بوده است، لذا به نظر می‌رسد با تحقیقات بیشتر در آینده بتوان از این گیاه در تسکین درد بهره برد.
Keywords [Persian]
مرزه بختیاری، ضد التهاب، ضد درد، آزمون رایزینگ، آزمون فرمالین
References
Amanlou, M., Dadkhah, F., Salehnia, A. and Farsam, H. 2005. An anti-inflammatory and anti-nociceptive effects of hydroalcoholic extract of Satureja khuzistanica Jamzad extract. Journal of Pharmacy & Pharmaceutical Sciences, 8(1):102-106.
Amin, G.R. 1991. Popular Medicinal Plants of Iran, vol. 1. Ministry of Health Publications, Tehran, PP: 103-104.
Atta, A.H. and Alkofahi, A. 1998. Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. Journal of Ethnopharmacology, 60: 117–124.
Aydin, S., Ozturk, Y., Beis, R. and Baser, K.H.C. 1996. Investigation of Origanum onites, Sideritiscongesta and Saturejacuneifolia essential oils for analgesic activity. Phytotheray Research, 10: 342-344.
Coderre, T.J. and Melzack, R. 1992. The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. Journal of Neuroscience, 12: 3665-3670.
Choi, J.H., Jung, B.H., Kang, O.H., Choi, H.J., Park, P.S., Cho, S.H., Kim, Y.C., Sohn, D.H., Park, H., Lee, J.H. and Kwon, D.Y. 2006. The anti-inflammatory and anti-nociceptive effects of ethyl acetate fraction of Cynanchipaniculati radix. Biological & Pharmaceutical Bulletin, 29: 971-975.
Christiane, O.C., Ianna, W.F., Edfranck, S.O., Vanderlei, Rodrigues, J.A.G., Quinder, A.G., Fontes, B.P., Queiroz, I.N.L., Menezes, D.B., Bezerra, M.M., Silva, A.A.R., Chaves, H.V., Jorge, R.J.B., Evangelista, J.S.A.M., and Benevides, N.M.B. 2012. Antinociceptive and Anti-Inflammatory Activities of Sulphated Polysaccharides from the Red Seaweed Gracilaria cornea, Basic & Clinical Pharmacology & Toxicology, 110: 335-341.
Guyton, A.C. and Hall, J.E. 2011. Text book of medicinal physiology, 11th ed. Saunders/Elsevier, PP: 264-276.
Hajhashemi, V., Ghannadi, A. and Pezeshkian, S.K. 2002. Antinociceptive and anti-inflammatory effects of Saturejahortensis L. extracts and essential oil. Journal of Ethnopharmacology, 82: 83-87.
Hajhashemi, V. and Klooshani, V. 2013. Antinociceptive and anti-inflammatory effects of Urtica dioica leaf extract in animal models. Avicenna Journal of Phytomedicine, 3(2):193-200.
Hunskaar, S. and Hole, K. 1987. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain, 30:103-114.
Josélia, A.L., Thiago, W.R.C., Leandro, L.S., Analuísa, P.M. and Angelo, C.P. 2016. Antinociceptive and anti-inflammatory effects of a Geissospermumvellosiistem bark fraction. Anais da Academia Brasileira de Ciências, 88(1): 237-248.
Katzung, B.G. and Trever, A.J. 2009. Bacic and clinical pharmacology, 13th ed. McGraw- Hill Education, PP: 678-680.
Koster, R., Anderson, M. and De Beer, E.J. 1959. Acetic acid for analgesic screening. Fedral Proceedings, 18: 412-417.
Moalem, G. and Tracey, D.J. 2006. Review – Immune and inflammatory mechanisms in neuropathic pain. Brain Research Reviews, 5:1240–64.
Prasoon, P., Gupta, S., Kumar, R., Gautam, M., Kaler, S. and Ray, S.B. 2016. Role of fosaprepitant, a neurokinin Type 1 receptor antagonist, in morphine-induced antinociception in rats. Indian Journal Pharmacology, 48(4):394-398.
Sefidkon, F. and Jamzad, Z. 2000. Essential Oil of Satureja bachtiarica Bunge. Journal of Essential Oil Research, PP: 545-546.
Shibata, M., Ohkubo, T., Takahashi, H. and Inoki, R. 1989. Modified formalin test: characteristic biphasic pain response. Pain, 38: 347-352.
Tjolsen, A., Berge, O.G., Hunskaar, S., Rosland, J.H. and Hole, K. 1992. The formalin test: an evaluation of the method. Pain, 51: 5-17.
Zandi Esfahan, S., Saghaei, F., Ghasemi Pirbalooti, A. and Zandi Esfahan, E. 2013. Analgesic and anti-inflammatory effects of ethanolic extract of Thymus daenensis Celak. in mice. Iranian Journal of Medicinal and Aromatic Plants, 30(6): 977-984.
Zargari, A. 1990. Medicinal Plants, vol. 4. Tehran University Publications, Tehran, PP: 42-45.
Top