The effect of hydroalcoholic extracts from Taraxacum officinale on blood indicators of kidney and liver functions in male rats

Document Type: Original article

Authors

1 D.V.M. Graduate, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

2 Department of clinical Sciences, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran

Abstract

Background & Aim:Evaluation of the effects of medicinal herbs on the metabolism and physiology of the body is considered as one of the fundamental researches about the use of herbs in medicine. The present study aimed to investigate the effects of hydroalcoholic extract of Dandelion (Taraxacum officinale) leaf on liver and kidney function of the rats in normal physiological conditions.
Experimental: The Wistar adult male rats (n=32) were divided into 4 groups of control, 50, 100 and 200 based on the concentration of the hydroalcoholic extract fed to rats (mg/kg body weight). Dandelion leaf extract was administered by gavage for 20 days. Blood samples were taken from the heart to assess the health parameters of the liver (cholesterol, triglyceride and liver enzymes) and kidney (urea, urea nitrogen, and creatinine).
Results: The concentrations of cholesterol and triglyceride were significantly increased in the extract-treated groups compared to the control. Levels of Gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST) were not significantly different between the treated groups and the control. However, alanine aminotransferase (ALT) levels were significantly increased in the extract-treated groups. Kidney health assessment showed that consumption of Dandelion leaf extract reduced the concentrations of urea, urea nitrogen, and creatinine. In addition, the concentration of these indicators at lower doses of the extract (50, was more significant.
Recommended applications/industries: The present study showed that under normal physiological conditions; consumption of hydroalcoholic extract of Dandelion leaf at low doses had no negative effects on liver and kidney functions.

Keywords


Article Title [Persian]

تأثیر عصاره های هیدروالکلی Taraxacum officinale بر شاخص های خونی کلیه و عملکرد کبد در موش های صحرایی نر

Authors [Persian]

  • آرمان راوش 1
  • محسن جعفریان دهکردی 2
  • مریم کریمی 2
1 دانش آموخته دکتری حرفه ای دامپزشکی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد شهرکرد، شهرکرد، ایران
2 گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی، واحد شهرکرد، شهرکرد، ایران
Abstract [Persian]

Background & Aim:Evaluation of the effects of medicinal herbs on the metabolism and physiology of the body is considered as one of the fundamental researches about the use of herbs in medicine. The present study aimed to investigate the effects of hydroalcoholic extract of Dandelion (Taraxacum officinale) leaf on liver and kidney function of the rats in normal physiological conditions.
Experimental: The Wistar adult male rats (n=32) were divided into 4 groups of control, 50, 100 and 200 based on the concentration of the hydroalcoholic extract fed to rats (mg/kg body weight). Dandelion leaf extract was administered by gavage for 20 days. Blood samples were taken from the heart to assess the health parameters of the liver (cholesterol, triglyceride and liver enzymes) and kidney (urea, urea nitrogen, and creatinine).
Results: The concentrations of cholesterol and triglyceride were significantly increased in the extract-treated groups compared to the control. Levels of Gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST) were not significantly different between the treated groups and the control. However, alanine aminotransferase (ALT) levels were significantly increased in the extract-treated groups. Kidney health assessment showed that consumption of Dandelion leaf extract reduced the concentrations of urea, urea nitrogen, and creatinine. In addition, the concentration of these indicators at lower doses of the extract (50, was more significant.
Recommended applications/industries: The present study showed that under normal physiological conditions; consumption of hydroalcoholic extract of Dandelion leaf at low doses had no negative effects on liver and kidney functions.

Keywords [Persian]

  • Taraxacum officinale leaf
  • hydroalcoholic extract
  • Rat
  • liver
  • kidney
Ahmadiyeh, A. 2001. By nature in the sick bed. Iqbal Publications, Tehran. pp. 11-12.

Blog, J. and Studoula, J. 2005. Medicinal Plants. Ghoghnos Publications, Tehran. pp 15.

Blumenthal, M., Goldberg, A. and Brinckmann, J. 2000. Herbal Medicine: Expanded Commission E monographs. Integrative Medicine Communications.

Bortis, K. 2000. Principles of Clinical Biochemistry of Tate. Andisheh Rafi Publications. pp. 449-568.

Chevallier, A. 2016. Encyclopedia of Herbal Medicine: 550 Herbs and Remedies for Common Ailments. Penguin, pp141.

Cho, J.Y., Kim, E.J. and Lee, S.M. 2015. Effects of Dandelion (Taraxzcum coreanum) Supplementation on Milk Yield, Milk Compositions and Blood Characteristics in Lactating Dairy Cows. JKSGFS., 35: 217-224.

Cho, S.Y., Park, J.Y., Park, E.M., Choi, M.S., Lee, M.K., Jeon, S.M. and Park, Y.B. 2002. Alternation of hepatic antioxidant enzyme activities and lipid profile in streptozotocin-induced diabetic rats by supplementation of dandelion water extract. Clinica Chimica Acta., 317: 109-117.

Di Cerbo, A., Iannitti, T., Guidetti, G., Centenaro, S., Canello, S. and Cocco, R. 2018. A nutraceutical diet based on Lespedeza spp., Vaccinium macrocarpon and Taraxacum officinale improves spontaneous feline chronic kidney disease. Physiological Reports, 6: e13737.

Gonzalez-Castejon, M., Visioli, F. and Rodriguez-Casado, A. 2012. Diverse biological activities of dandelion. Nutrition reviews, 70: 534-547.

Karakus, A., Deger, Y. and Yildırım, S. 2017. Protective effect of Silybum marianum and Taraxacum officinale extracts against oxidative kidney injuries induced by carbon tetrachloride in rats. Renal failure, 39: 1-6.‏

Modaresi, M. and Resalatpour, N. 2012. The Effect of Taraxacum officinale Hydro Alcoholic Extract on the Blood Cell Counts in Mice. Armaghanedanesh, 17:423-438.

Mohebbi, A. 2012. Medicinal-Industrial Plants in Iran. Library Publications, Tehran. pp. 10-12.

Mojabi, A. 2011. Veterinary Clinical Biochemistry. Tehran: Noorbakhsh Publications. pp. 39-387.

Moon, S.J., Shin, S.S., Son, C.H., Oh, K.S., Kim, H.J., Jung, J.Y. and Suh, G.H. 2017. Protective effects of dandelion extract against liver damage by repeated administration of thioacetamide in rats. The Korean Journal of Veterinary Service, 40: 107-117.

Yarnell, E. and Abascal, K. 2009. Dandelion (Taraxacum officinale and T. mongolicum). Integrative Medicine, 8: 35-38.

You, Y., Yoo, S., Yoon, H.G., Park, J., Lee, Y.H. 2010. In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food and Chemical Toxicology, 48: 1632-1637.