Evaluation of Kelussia odoratissima Mozaff. extract on serum biochemical parameters and hepatica enzymes in the Persian Shepherd dogs

Document Type: Original article

Authors

1 Graduated From the Veterinary Medicine, Faculty of veterinary medicine, Islamic Azad university of Shahrekord, Shahrekord, Iran;

2 Faculty of Veterinary Medicine, Shahre Kord Branch, Islamic Azad University, Shahre Kord, Iran.

3 Department of Medical Plants,Research Center of Medicinal Plants & Ethno-veterinary, Islamic Azad university of Shahrekord, Shahrekord, Iran

Abstract

Background & Aim:Nowadays, attention has increasingly been directed toward the treatment of animal’s disease using medicinal herbs. This research was conducted to evaluate the impact of Kelussia odoratissima Mozaff extract on dog serum biochemical parameters and hepatica enzymes over time.
Experimental: 32 adult dogs were randomly assigned to four groups. The first (control) group did not receive any pharmaceutical compound. The second group received 150 mg/kg of hydro-alcoholic extract of k.odoratissima. The third and the forth groups received 300 and 450 mg/kg of the extract, respectively. Finally, the blood samples were collected on days 0, 5, 10, and 15 for serum biochemical parameters analysis including the level of blood sugar, cholesterol, triglyceride, LDL and HDL, alanine aminotransferase, aspartate aminotransferases, and alkaline phosphatase.
Results: Comparing to the control group, the levels of fast blood sugar, low density lipoprotein, high density lipoprotein, trigliceride, cholesterol, Alanin aminotransferase and aspartate aminotransferase in treated groups were significantly different over time and at various doses of the extract (P<0.05). However, the level of Alkaline-phosphatase (ALP) factor did not change throughout this study (P>0.05).
Recommended applications/industries: Considering the results of this study, anti-diabetic, anti-atherosclerotic and antioxidant effects of Kelussia odoratissima can be concluded. Then, the possibility of employing K. odoratissima extract in drugs for the treatment of mentioned diseases can be suggested.

Keywords


Article Title [Persian]

بررسی اثرعصاره گیاه کرفس کوهی بر تغییرات پروفایل لیپیدی سرم و آنزیم های کبدی در سگ های نژاد ژرمن شفرد

Authors [Persian]

  • اردلان معینی 1
  • سام ترکان 2
  • فاطمه ملک پور 3
1 دانش آموخته دانشکده دامپزشکی دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
2 گروه علوم درمانگاهی، دانشکده دامپزشکی، دانشگاه آزاد اسلامی واحد شهرکرد، شهرکرد، ایران
3 گروه گیاهان داروئی،مرکز پژوهش های گیاهان دارویی و دام پزشکی سنتی واحد شهرکرد، دانشگاه آزاد اسلامی، شهرکرد، ایران
Abstract [Persian]

Background & Aim:Nowadays, attention has increasingly been directed toward the treatment of animal’s disease using medicinal herbs. This research was conducted to evaluate the impact of Kelussia odoratissima Mozaff extract on dog serum biochemical parameters and hepatica enzymes over time.
Experimental: 32 adult dogs were randomly assigned to four groups. The first (control) group did not receive any pharmaceutical compound. The second group received 150 mg/kg of hydro-alcoholic extract of k.odoratissima. The third and the forth groups received 300 and 450 mg/kg of the extract, respectively. Finally, the blood samples were collected on days 0, 5, 10, and 15 for serum biochemical parameters analysis including the level of blood sugar, cholesterol, triglyceride, LDL and HDL, alanine aminotransferase, aspartate aminotransferases, and alkaline phosphatase.
Results: Comparing to the control group, the levels of fast blood sugar, low density lipoprotein, high density lipoprotein, trigliceride, cholesterol, Alanin aminotransferase and aspartate aminotransferase in treated groups were significantly different over time and at various doses of the extract (P<0.05). However, the level of Alkaline-phosphatase (ALP) factor did not change throughout this study (P>0.05).
Recommended applications/industries: Considering the results of this study, anti-diabetic, anti-atherosclerotic and antioxidant effects of Kelussia odoratissima can be concluded. Then, the possibility of employing K. odoratissima extract in drugs for the treatment of mentioned diseases can be suggested.

Keywords [Persian]

  • Dog
  • Extract
  • Hepatica enzyme
  • Kelussia Odoratissima Mozaff
  • Lipid profiles
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