Clinical studies on the treatment of psoriasis in Unani system of medicine: A systemic review

Document Type: Review article

Author

Department of Unani, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India

Abstract

Background & Aim:Psoriasis is a chronic inflammatory skin disease. In Unani system of medicine, psoriasis is termed as Daʹus Sadaf or Taqashshur-i Jild which has been treated successfully since antiquity with various single and compound drugs. In recent years, various clinical studies have been conducted to validate the claims of Unani medicine in the management of psoriasis. The aim of this study was to review the published scientific clinical studies, performed to evaluate the safety and efficacy of Unani drugs in the treatment of psoriasis.
Experimental: Author searched four databases for psoriasis, using the terms “Daʹus Sadaf OR psoriasis”, “Taqashshur-i Jild OR psoriasis”, “Unani medicine and psoriasis”. Author also hand searched journals available in the library of Central Council for Research in Unani Medicine & Jamia Hamdard (New Delhi) and All India Institute of Medical Sciences (Raipur). All published clinical studies with Unani intervention were included in this review.
Results: A total of 58 articles were reviewed; out of them 46 articles based on animal studies, epidemiological reports, studies of general concepts were discarded leading to inclusion of 12 articles. Different Unani drugs were used in the trials. Although each clinical study reported beneficial effect, but there were very few trials that were controlled and randomized.
Recommended applications/industries: Various clinical studies evaluating the safety and efficacy of Unani drugs in the treatment of psoriasis have been carried out, but well-designed randomized controlled clinical trials (RCTs) still need to be conducted using standardized tools to scientifically validate the safety and efficacy of Unani drugs in the treatment of psoriasis.

Keywords


Article Title [Persian]

مطالعات بالینی در مورد درمان پسوریازیس در سیستم پزشکی یونانی: یک بررسی سیستمیک

Author [Persian]

  • عدنان مستان
موسسه علوم پزشکی هند ، هند.
Abstract [Persian]

Background & Aim:Psoriasis is a chronic inflammatory skin disease. In Unani system of medicine, psoriasis is termed as Daʹus Sadaf or Taqashshur-i Jild which has been treated successfully since antiquity with various single and compound drugs. In recent years, various clinical studies have been conducted to validate the claims of Unani medicine in the management of psoriasis. The aim of this study was to review the published scientific clinical studies, performed to evaluate the safety and efficacy of Unani drugs in the treatment of psoriasis.
Experimental: Author searched four databases for psoriasis, using the terms “Daʹus Sadaf OR psoriasis”, “Taqashshur-i Jild OR psoriasis”, “Unani medicine and psoriasis”. Author also hand searched journals available in the library of Central Council for Research in Unani Medicine & Jamia Hamdard (New Delhi) and All India Institute of Medical Sciences (Raipur). All published clinical studies with Unani intervention were included in this review.
Results: A total of 58 articles were reviewed; out of them 46 articles based on animal studies, epidemiological reports, studies of general concepts were discarded leading to inclusion of 12 articles. Different Unani drugs were used in the trials. Although each clinical study reported beneficial effect, but there were very few trials that were controlled and randomized.
Recommended applications/industries: Various clinical studies evaluating the safety and efficacy of Unani drugs in the treatment of psoriasis have been carried out, but well-designed randomized controlled clinical trials (RCTs) still need to be conducted using standardized tools to scientifically validate the safety and efficacy of Unani drugs in the treatment of psoriasis.

Keywords [Persian]

  • Psoriasis
  • Daʹus Sadaf
  • Taqashshur-i Jild
  • Unani medicine
  • Psoriasis Area and Severity Index (PASI)
Akhtar, S., Khan, B.D. and Aleem, S. 2011. Therapeutic Evaluation of Itrifal-e- Shahatra and Roghan-e-Babchi in Case of Daʹus Sadaf, Hippocratic Journal of Unani Medicine, 6(2): 11-22.

Arzani, A. 2001. Mizan al-ibb (Urdu translation by Kabir al-Din HM). Idara Kitab al-Shifa, New Delhi, pp. 257.

Arzani, A. 1875. Tibb-i Akbar (Urdu translation by Hussain M). Faisal Publications, Deoband, pp. 739-740.

Augustin, M., and Radtke, M.A. 2014. Quality of life in psoriasis patients. Expert Review of Pharmaco­economics and Outcomes Research, 14(4): 559-568.

Boehncke, W.H., and Schon, M.P. 2015. Psoriasis. Lancet, 386(9997): 983-994.

Danielsen, K., Olsen, A.O., Wilsgaard, T., and Furberg, A.S. 2013. Is the prevalence of psoriasis increasing? A 30-year follow-up of a population-based cohort. British Journal of Dermatology, 168(6): 1303-1310.

De Korte, J., Sprangers, M.A., Mombers, F.M., and Bos, J.D. 2004. Quality of life in patients with psoriasis: A systematic literature review. Journal of Investigative Dermatology Symposium Proceedings, 9(2): 140-147.

Fatima, G., Siddiqui, S.A., Jabeen, A., Qamaruddin, and Kazmi, M.H. 2019. Therapeutic Effect of Majun Mundi and Qayruti Karnab in Daʹus Sadaf (Psoriasis): A Case Series, TANG-Humanitas Medicine, 9(4):e8.

Fuji, R., Mould, J.F.J., Tang, B., Brandt, H., Pomerantz, D., Chapnick, J. et al. 2012. Burden of disease in patients with diagnosed psoriasis in Brazil: results from 2011 National Health and Wellness Survey (NHWS). Value Health, 15(4):A107.

Gibbs, S. 1996. Skin disease and socioeconomic conditions in rural Africa: Tanzania. International Journal of Dermatology, 35(9): 633-639.

Harden, J.L., Krueger, J.G. and Bowcock, A.M. 2015. The immunogenetics of psoriasis: A comprehensive review. Journal of Autoimmunity, 64: 66-73.

Hubal, I. 2007. Kitab al-Mukhtarat fiʹl Tibb (Urdu translation). Vol. 2,4. CCRUM, Ministry of Health and Family Welfare, New Delhi, pp. 51, 85, 118, 120-23, 185- 86, 189-190, 209, 218, 224, 239, 251, 263, 266-267, 282.

Jilani, G. 1996. Makhzan al-Hikmat. Ejaz Publishing House, New Delhi, pp. 698-699.

Khan, A. 1289 Hijri. Iksir-i Aʹzam (Farsi). Vol. 4. Matbaʹ Nizami, Kanpur, pp. 511.

Khan, A. 2006. Rumuz-i Aʹẓam(Farsi). 2nd ed. Vol. 1,2. CCRUM, Ministry of Health and Family Welfare, New Delhi, pp.185, 287, 427, 404.

Khan, Q. 2019. Efficacy of Unani formulations in psoriasis: A case series study at NIUM hospital. International Journal of Unani & Integrative Medicine, 3(4):110-111.

Khanna, N., Nazli, T., Siddiqui, K.M., Kalaivani, M. and Rahman R. 2018. A non-inferiority randomized controlled clinical trial comparing Unani formulation & psoralen plus ultraviolet A sol in chronic plaque psoriasis. Indian Journal of Medical Reseatch, 147:66-72.

Kimball, A.B., Jacobson, C., Weiss, S., Vreeland, M.G. and Wu, Y. 2005. The psychosocial burden of psoriasis. American Journal of Clinical Dermatology, 6(6):383-392.

Lone, A.H., Ahmad, T. and Naiyar, A.H. 2011. Clinical evaluation of efficacy of MajoonUshba and Roghane Hindi in the management of psoriasis: A randomized single-blind, placebo-controlled study. Journal of Ayurveda & Integrative Medicine, 2(1): 26-31.

Majusi. 2010. Kamil al-Sanaʹa al-Tibbiyya (Urdu translation by Kanturi GH). Vol. 1,2. Idara Kitab al-Shifa, New Delhi, pp. 252, 255-256, 431-433.

Mohsin, M., Shoaib, M., and Anas, M. 2016. A Clinical Study of Psoriasis and Psoriatic Arthritis with Application of Wet Cupping and Majun ChobChini in its Treatment, Hippocratic Journal of Unani Medicine, 11(3):1-7.

Parisi, R., Symmons, D.P.M., Griffiths, C.E.M. and Ashcroft, D.M. 2013. Identification and Management of Psoriasis and Associated Co-morbidity (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. Journal of Investigative Dermatology, 133(2):377-385.

Qureshi, M.A. and Bano, H. 2019. Clinical observation of Unani medicine in the treatment of Psoriasis: A Case Study. Indian Journal of Traditional Knowledge, 8(1):190-192.

Rashid, R. 2012. Therapeutic Evaluation of Unani Formulations in the Management of Psoriasis, Department of Moalajat, National Institute of Unani Medicine, Bangalore.

Russo, P.A.J., Ilchef, R. and Cooper, A.J. 2004. Psychiatric morbidity in psoriasis: A review. Australasian Journal of Dermatology, 45(3): 155-161.

Sampogna, F., Tabolli, S. and Abeni, D. 2012. IDI Multipurpose Psoriasis Research on Vital Experiences (IMPROVE) investigators. Living with psoriasis: prevalence of shame, anger, worry, and problems in daily activities and social life. Acta Dermato-Venereologica, 92(3):299-303.

Shiraz, M., Ahmed, N.Z., Parvez, A. and Ahmed, H. 2017. Anti Psoriatic Effect of Leech Therapy in Psoriasis - A Case Report. Hippocratic Journal of Unani Medicine, 12(3):43-50.

Siddiqui, M.M.H., Khan, S. and Aleem, S. 2009. Effect of Psoralia corilifolia Linn. and Marham Gulabi in the management of Daʹus Sadaf (Psoriasis). Indian Journal of Traditional Knowledge, 8(3): 425-430.

Siddiqui, M.M.H., Khan, S. and Aleem, S. 2015. Clinical and Histopathological Evaluation of the Effects of Psoralia corylifolia Linn. Seeds and Marham Gulabi in Da-us-Sadaf (Psoriasis) A Case Study. Hamdard Medicus, 58(2):43-50.

Siddiqui, R.H.F.M., Haq, M.E., Nawaz, W.N.S. and Hassan S. 2019. Clinical efficacy of Unani medicine in psoriasis: A case series study. The Pharma Innovation Journal, 8(8): 242-243.

Stern, R.S., Nijsten, T., Feldman, S.R., Margolis, D.J. and Rolstad, T. 2004. Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction. Journal of Investigative Dermatology Symposium Proceedings, 9(2):136-139.

Tang, M.M., Chang, C.C., Chan, L.C. and Heng, A. 2013. Quality of life and cost of illness in patients with psoriasis in Malaysia: A multicenter study. International Journal of Dermatology, 52(3):314-322.

WHO. 2016. Global Report on Psoriasis. Available at https://apps.who.int/iris/bitstream/handle/10665/204417/9789241565189_eng.pdf.psoriasis;jsessionid=54912784D28C9F36ECCD45471AC5775B?sequence=1 pp. 5-7. (last accessed on 28 July 2020).

Zuhr, I. 1986. Kitab al-Taysir (Urdu translation). CCRUM, Ministry of Health and Family Welfare, New Delhi, pp. 204-205.