Phyto-pharmacological review of Calotropis procera – A natures drug house in tropical countries

Document Type: Review article

Authors

1 Department of Applied Chemistry, Sardar Bhagwan Singh University, Balawala, Dehradun, India,.

2 Department of Applied Chemistry, Sardar Bhagwan Singh University, Balawala, Dehradun, India, 248100;

3 Department of Applied Chemistry, Sardar Bhagwan Singh University, Balawala, Dehradun, India.

4 Department of Biochemistry and Biotechnology, Sardar Bhagwan Singh University, Balawala, Dehradun, India.

Abstract

Background & Aim: The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 121 pharmaceutical products have been discovered based on the information obtained from the traditional healers. In the present study, we thoroughly investigated the phyto-pharmacological potential of Calotropis procera which is extremely effective as medicine and its phyto-constituents show strong antioxidant properties.
Results: The world health organization has estimated that world population of about 80 % from developing countries depends on herbal medicine for their basic health care needs. Calotropis procera is an important drug of Ayurvedic medicine and researchers are exploring the therapeutic potential of this plant. Calotropis is a plant with excellent medicinal properties which is used for curing different human ailments.
Recommended applications/industries: The present review article provides a viewpoint on phytopharmacological potential of Calotropis procera which could be beneficial for future research on development of better and economically superior therapeutic agents.

Keywords

Article Title [Persian]

بررسی شیمی - داروئی Calotropis procera - یک داروی خانگی طبیعی در کشورهای گرمسیری

Authors [Persian]

  • ورشا پارکا 1
  • نور فاطما 2
  • دیپاک کومار 3
  • الوک میتانی 3
  • سانتوش کومار کارن 4
1 گروه شیمی کاربردی ، دانشگاه سردار باگوان سینگ ، بالاوالا ، دهردون ، هند.
2 گروه شیمی کاربردی ، دانشگاه سردار باگوان سینگ ، بالاوالا ، دهردون ، هند.
3 گروه شیمی کاربردی ، دانشگاه سردار باگوان سینگ ، بالاوالا ، دهردون ، هند.
4 گروه بیوشیمی و بیوتکنولوژی ، دانشگاه سردار باگوان سینگ ، بالاوالا ، دهردون ، هند.
Abstract [Persian]

Background & Aim: The use of traditional medicine and medicinal plants in most developing countries, as a normative basis for the maintenance of good health, has been widely observed. In the last century, approximately 121 pharmaceutical products have been discovered based on the information obtained from the traditional healers. In the present study, we thoroughly investigated the phyto-pharmacological potential of Calotropis procera which is extremely effective as medicine and its phyto-constituents show strong antioxidant properties.
Results: The world health organization has estimated that world population of about 80 % from developing countries depends on herbal medicine for their basic health care needs. Calotropis procera is an important drug of Ayurvedic medicine and researchers are exploring the therapeutic potential of this plant. Calotropis is a plant with excellent medicinal properties which is used for curing different human ailments.
Recommended applications/industries: The present review article provides a viewpoint on phytopharmacological potential of Calotropis procera which could be beneficial for future research on development of better and economically superior therapeutic agents.

Keywords [Persian]

  • Calotropis procera
  • Phyto-constituents
  • Pharmacological activity
  • Latex

References

Akhtar, N. and Malik, A. 1998. Proceragenin, an antibacterial cardenolide from Calotropis procera. Phytochemistry, 31(8): 2821-2824.

Alam, P. and Ali, M. 2009. Phytochemical investigation of Calotropis procera (Ait) roots. Indian Journal of chemistry, 48B: 443-446.

Ali, A.M. Mackeen M.M, and El- Sharkawy S.H. 1996. Antiviral and cytotoxic activities of some plants used in Malaysian indigenous medicines. Pertanika Journal of Tropical Agricultural Science, 19: 129.

Alikhan, I. and Khanum, A. 2005. Medicinal and Aromatic Plants of India, Ukaaz Publication, 133-134.

Al-Yahya, M.A., Al-Meshal I.A., Mossa, J.S., and Tariq, M. 1985. Phytochemical and pharmacological studies on Calotropis procera. Proceeding of the 3rd International Conference of Traditional and Folk Medicine. Lecatecas, Mexico.

Anis, M., Sharma, M.P. and Muhammad, I. 2000. Herbal ethno-medicine of the Gwaliar ForestDivision in Madhya Pradesh, India. Pharmaceutical Biology, 38(4): 241-253.

Anonymous, 2010. The Ayurvedic Pharmacopoeia of India. Government of India Ministry of Health and Family Welfare Department of Ayush, New Dehli, India, 1(1): 11-14.

Ansari, S.H. and Ali, M. 2000. New oleanene triterpenes from root bark of Calotropis procera(Ait) R.Br. Indian journal of chemistry, 39B: 287-290.

Ansari, S.H. and Ali, M. 1999. New oleanene triterpenes from root bark of Calotropis procera. Medicinal and Aromatic Plant Science, 21(4): 978-981.

Ansari, S.H. and Ali, M. 2001. Norditerpenic ester and pentacyclic triterpenoids from root bark of Calotropis procera (Ait) R. Br. Pharmazie, 56(2):175-177.

Atef G.H., Elgamal, M.H.A., Morsy, N.A.M., Duddeck, H., Kovacs, J. and Toth, G. 1999. Two cardenolides from Calotropis procera. Journal of Magnetic Resonance Chemistry, 17: 754-757.

Bhogaonkar, P.Y. and Kadam, V.N. 2007. Herbal antidotes used for snakebite by banjara people of Umarkhed region in Maharashtra, India. Ethnobotany, 19: 71-78.

Danmalan, U.H., Abdul, R.A., Yaro, A.H. and Magaji, M.G. 2007. Phytochemical and anticonvulsant activity of the ethanol extracts of the root bark of calotropis procera. Chemical Class Journal, 4: 113-116.

Dhar, M.L., Dhar, M.M., Dhawan, B.N., Mehrotra, B.N. and Ray C. 1968. Screening of Indian medicinal plants for biological activity, Part I. Indian Journal of Experimental Biology, 6: 232-247.

Evans, W.C. 2005. Trease and Evans Pharmacognosy. Saunders an Imprint of Elsevier, 41-47.

Grieve, M.M. 1994. A Modern Herbal. London: Tigers Book International, 10: 154.

Gupta, J. and Ali, M. 2000. Rare chemical constituents from Calotropis gigantea roots. Indian Journal of pharmaceutical sciences, 62(1),29-32.

Iqbal, Z., Lateef, M. and Jabbar, A. 2005. Anthelmintic activity of Calotropis procera (Ait.), flowers in sheep. Journal of Ethnopharmacology, 102 (2): 256-261.

Jain, A., Katewa, S.S., Galav, P. and Nag, A. 2008. Some therapeutic uses of biodiversity among the tribals of Rajasthan, India. Journal of Traditional Knowledge, 7 (2): 256-262.

Jalalpure, S.S. 2009. Anticonvulsant effects of Calotropis procera root in rats. Pharmaceutical biology, 47 (2): 162-167.

Jan, S., Ajabkhan, M., Uddin, S., Murad, W., Hussain, M. and Ghani, A. 2008. Herbal remedies used for gastrointestinal disorders Kaghan Valley, Nwep, Pakistan. Pakistan Journal of Weed Science Research, 14(3-4):169-200.

Joshua, K. 2006. Conservation of indigenous medicinal botanicals in Ekiti State, Nigeria. Journal of .Zhejiang University Science B, 7(9): 713-718.

Kew, F. 1985. The useful plants of west tropical Africa, 2 nd ed. Vol. 1. In Burkill, H.M. Royal Botanical Gardens, pp. 219-222.

Kokate, C.K. 1994. Practical pharmacognosy. Vallabh Prakashan; pp. 115-121.

Kumar, A. 2009. Some important medicinal plants from different regions of Rajasthan, Scientific Biology, Science.

Kumar, V.I. and Basu, N. 1994. Anti-inflammatory activity of the latex of Calotropis procera. Journal of Ethnopharmacology, 44: 123-125.

Kumar, V.L., Padhy, B.M., Sehgal, R. and Roy, S. 2005. Antioxidant and protective effect of latex of Calotropis procera against alloxan-induced diabetes in rats. Journal of Ethnopharmacology, 102 (3): 470-473.

Kumar, V.L., Sangraula, H., Dewan, S. and Kumar, S. 2001. Antidiarrheal activity of the latex of Calotropis procera. Journal of Ethnopharmacology, 76 (1):115-118.

Kumar, V.L., Sangraula, H. and Dewan, S. 2000. Preliminary studies on the analgesic activity of latex of Calotropris procera. Journal of Ethnopharmacology, 73(1-2): 307-311.

Markouk, M., Bekkouche, K., Larhsini, M., Bousaid, M., Lazrek, H.B. and Jana, M. 2000. Evaluation of some Moroccan medicinal plant extracts for larvicidal activity. Journal of Ethnopharmacology, 73 (1-2): 293-297.

Mascolo, N., Jain, R., Jain, S.C. and Capasso, F. 1989. Ethnopharmacologic investigation of ginger (Zingiber officinale). Journal of Ethnopharmacology, 27 (1-2): 129-140.

Mathura, R. and Gupta, S.K. 2009. Anti-tumor studies with extracts of Calotropis procera (Ait.) R.Br. root employing Hep2 cells and their possible mechanism of action. Indian Journal of Experimental Biology, 47 (5): 343-348.

Meena, A.K., Yadav, A. and Raw, M.M. 2011. Ayurvedic uses and pharmacological activities of Calotropis procera Linn. Asian journal of traditional medicines, 6(2): 45-53.

Mittal, A. and Ali, M. 2011. Phytochemical investigation of the roots of Calotropis procera (Ait) R.Br. international journal of pharmacy, 2(9):52-54.

Mukherjee, B., Bose, S. and Dutta, S.K. 2010. Phytochemical and pharmacological investigation of fresh flower of extrtact of Calotropis procera linn. International Journal of Pharmaceutical Sciences and Research, 1(12): 182-187.

Murti, P.B.R. and Seshadri, T.R. 1943. Chemical composition of Calotropis gigantea: Part1. Wax and Resin components of the latex. Proceeding of the Indian Academy Science, 18: 145-159.

Murti, P.B.R. and Seshadri, T.R. 1945. Chemical composition of Calotropis gigantea : Part V. Further examination of the latex and root bark. Proceeding of the Indian Academy Science, 21: 143-147.

Negi, C.S., Navtiyal, S., Dasila, L., Rao, K.S. and Maikhuri, R.K. 2002. Ethnomedicinal plant uses in a small tribal community in a part of central Himalaya, India, Journal of Human Ecology, 14 (1): 23-31.

Palejkar, C.J., Palejkar, J.H., Patel, M.A. and Patel, A.J. 2012. A Comprehensive review on plant Calotropis gigantea. International Journal of Institutional Pharmacy and Life Sciences, 2(2): 463-470.

Parrota, J.A. 2001. Healing of plants of Penninsular India. AB International Wallingford, U.K., pp. 944

Rastogi, R.P. and Mehrotra, B.N. 1997. Compendium of Indian Medicinal Plant, Central Drug Research Institute, Lucknow, pp. 147.

Reddy, V.B. 2008. Use of various bio fencing plants in the control of human diseases by Lambda Tribe Inhabiting Nagaland District, A.P, India. Ethnobotanical Leaflets,12: 520-523.

Sen, S.K. and Behra, L.M. 2007. Ethnomedicinal plants used in touch therapy at Bargarh district of Orissa. Ethnobotany, 19: 100-104.

Setty, R.S., Quereshi, A.A., Swamy, V., Patil, T., Prakash, T., Prabhu, K. and Gouda, V. 2007. Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia, 78 (1): 451-454.

Sha, S.R.U., Hassan, G., Rehman, A. and Ahmed, I. 2006. Ethnobotanical studies of the flora of the district Musakhel and Barkhan in Balochistan. Pakistan. Pakistan Journal of Weed Science Research, 12(3): 199-211.

Sharma, P. and Sharma, J.D. 2000. In-vitro Schizontocidal screening of Calotropis procera. Fitoterapia, 71: 77-79.

Uddin, G., Rauf, A., Muhammad, N. and Mulik, N. 2012. Phytochemical and pharmacological studied of the whole plant of Calotropis procera. Middle-East Journal of medicinal Plants Research, 1(4): 71-74.

Vasconcelos, S.M.M. 2005. Antinociceptive activity of Calotropis procera latex in mice. Journal of Ethnopharmacology, 99(1): 125-129.

Yasmin, N,, Uddin, S.N., Mubassara, S. and Akond, M.A. 2008. Antioxidant and antibacterial activity of calotropis procera linn. Ammerican –Eurasian Journal of agricultural. and environmental science, 4(5): 550-553.

Journal of Medicinal Herbs,

Volume 10, Issue 4
Summer 2019
Pages 163-174

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