Approaches and therapeutic effects of Saffron (Crocus sativus L.) and Barberry (Berberis vulgaris) in the treatment and prevention of diseases: A review

Document Type : Review article


Department of Laboratory Science, Faculty of medicine, Semnan University of Medical Sciences, Semnan, Iran.



Background & Aim: Natural compounds as drugs have fewer and more cost-effective side effects that can be utilized as pharmacological and therapeutic approaches. Traditional medicine can be an efficacious resource in the development of research to treat diseases.
Experimental: In this review article, keywords including Saffron (Crocus sativus L.), Barberry (Berberis vulgaris), and their medicinal attributes were searched in prominent databases (such as Scopus, and Web of Science, etc.) and professional websites to collect the medicinal properties of Saffron, and Barberry.
Results: Saffron is one of the most important natural compounds that has a wide range of utilizations in traditional medicine and has effects such as anti-cancer, anti-depressant, antispasmodic, nerve sedative, appetizer and also barberry is another natural substance that has considerable influences such as anti-arrhythmia, sedative, reducing blood pressure (BP) and anti-cancer. Saffron and its bioactive components have been revealed to have anti-neurodegenerative influences.
Recommended applications/industries: In the present review article, we have made an endeavor to explore approach and therapeutic effects of Saffron and Barberry in the treatment of diseases in clinical trials and animal model studies. Research in clinical trials promising findings that support the role of barberry and saffron in ameliorating disease and safety, although more research is needed to prove their role in treating the disease


Article Title [فارسی]

رویکردها و اثرات درمانی زعفران (Crocus sativus L.) و زرشک (Berberis vulgaris) در درمان و پیشگیری از بیماری ها: مروری

Author [فارسی]

  • محمد سعیدی
گروه علوم آزمایشگاهی، دانشکده پزشکی، دانشگاه علوم پزشکی سمنان، سمنان، ایران.
Abstract [فارسی]

Background & Aim: Natural compounds as drugs have fewer and more cost-effective side effects that can be utilized as pharmacological and therapeutic approaches. Traditional medicine can be an efficacious resource in the development of research to treat diseases.
Experimental: In this review article, keywords including Saffron (Crocus sativus L.), Barberry (Berberis vulgaris), and their medicinal attributes were searched in prominent databases (such as Scopus, and Web of Science, etc.) and professional websites to collect the medicinal properties of Saffron, and Barberry.
Results: Saffron is one of the most important natural compounds that has a wide range of utilizations in traditional medicine and has effects such as anti-cancer, anti-depressant, antispasmodic, nerve sedative, appetizer and also barberry is another natural substance that has considerable influences such as anti-arrhythmia, sedative, reducing blood pressure (BP) and anti-cancer. Saffron and its bioactive components have been revealed to have anti-neurodegenerative influences.
Recommended applications/industries: In the present review article, we have made an endeavor to explore approach and therapeutic effects of Saffron and Barberry in the treatment of diseases in clinical trials and animal model studies. Research in clinical trials promising findings that support the role of barberry and saffron in ameliorating disease and safety, although more research is needed to prove their role in treating the disease.

Keywords [فارسی]

  • Saffron (Crocus sativus L.)
  • Barberry (Berberis vulgaris)
  • Therapeutic effects
  • Natural compounds
  • Traditional medicine
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